链球菌 (Streptococcus) 是一个Dysgalactiae亚种. 来自生病猪的等同性基因与人类菌株有遗传差异,并与多种药物耐药性有关
Fengyang Hsu1,2, Kayleigh Gauvin1,2, Kevin Li1,2
1Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
Microorganisms
|January 28, 2026
概括
链球杆菌dysgalactiae亚种. 在猪中形成独特的遗传分类,与人类菌株不同,并表现出显著的抗微生物耐药性. 持续对猪SDSE进行基因组监测至关重要.
科学领域:
- 兽医微生物学 兽医微生物学
- 基因组学就是基因组学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 链球杆菌dysgalactiae亚种. 奇形 (SDSE) 是一种已知的人类病原体.
- 大约100年来,SDSE已在猪身上被发现,但其猪种群结构仍未得到充分研究.
研究的目的:
- 调查猪中SDSE的种群结构.
- 为了确定猪和人类SDSE菌株之间的遗传关系.
- 描述猪SDSE的抗菌素耐药性概况和遗传决定因素.
主要方法:
- 来自加拿大北克的41个猪SDSE分离体 (2019-2022) 的核心基因组遗传学分析.
- 鉴定emm基因区域和兰斯菲尔德抗原位置的特征.
- 表型抗微生物敏感性测试和抗微生物耐药性基因的检测.
- 混合基因组组装以识别移动遗传元素.
主要成果:
- 确定了两种不同的猪SDSE类,从基因学上与人类主导血统分开.
- 与人类菌株相比,大多数猪分离品缺乏功能性EMM基因或改变了EMM区域.
- 观察到一个占主导地位的C组血统和一个少数的L组血统,反映了历史的血清组分布.
- 检测到高水平的抗四环素,类和林科萨米德耐药性,往往与特定的AMR基因和多药耐药性相关.
- 确定了携带AMR决定因素的整合性和可调动性元素.
结论:
- 猪SDSE代表了一个基因结构,与人类菌株不同的宿主适应的种群.
- 这些发现凸显了猪SDSE种群中显著的抗菌素耐药性潜力.
- 持续对猪SDSE进行基因组监测对于了解其演变和管理AMR至关重要.
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