饮食中补充的小素恢复了肠道屏障功能和微生物群平衡,在沙门氏菌感染的无特定病原体的小中
Chenxin Zhou1, Hui Liu2, Bowen Yang1
1College of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Microorganisms
|January 28, 2026
概括
在中,佩迪奥辛 (PP) 治疗有效地逆转了沙门氏菌 (Salmonella pullorum) 感染引起的负面健康影响,改善了肠道屏障功能和免疫反应. PP还积极调节了肠道微生物群的组成,突出了其治疗潜力.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 沙门氏菌 (Salmonella pullorum) 感染对家禽健康构成重大威胁,影响肠道屏障功能,脏和肝脏系统以及免疫调节.
- 肠道失生症和障碍障碍完整性是S. pullorum感染的关键病理特征,导致全身炎症和器官损伤.
- 一种细菌素佩迪奥辛 (PP) 已显示出抗微生物特性,但它对中S. pullorum诱导的病理学的特定影响需要详细的研究.
研究的目的:
- 评估儿科素 (PP) 对感染沙门氏菌的的肠道屏障功能,损伤和免疫调节的治疗作用.
- 调查PP治疗对受S. pullorum感染的肠道微生物群组成和多样性的影响.
- 阐明PP对S. pullorum感染的保护机制,重点关注炎症标志物和肠道完整性.
主要方法:
- 45只没有特定病原体的被分为对照组,感染S. pullorum和感染S. pullorum+接受PP治疗的组.
- 评估了关键的生理,免疫和炎症参数,包括和肝功能标志物,免疫球蛋白水平和细胞因子表达.
- 通过测量毛高度,毛与密室的比率以及紧密结合蛋白和粘蛋白的表达来评估肠道屏障完整性.
- 用16S rRNA测序分析了肠道微生物组成,以评估细菌种群的α-多样性和相对丰度,在属和属级别.
主要成果:
- S. pullorum感染显著增加了脏,肝脏,免疫和炎症标志物,同时降低了肠道的高度,与密室的比率和肠道紧密结合蛋白.
- 在感染后12天,PP治疗显著改善了这些有害影响,使大多数参数恢复到与对照组相比的水平.
- PP治疗部分恢复了肠道微生物群的α多样性,增加了诸如Firmicutes,Actinobacteria,Faecalibacterium和Lactobacillus等有益细菌的相对丰富性,并恢复了Proteobacteria和Verrucomicrobia.
结论:
- 佩迪奥辛 (PP) 有效地减轻肠道屏障损伤,减少免疫应激反应,并对的沙门氏菌 (Salmonella pullorum) 感染产生保护作用.
- PP的治疗效益与其调节肠道微生物群组成的能力有关,促进有益细菌的生长.
- 这些发现表明,PP是一种有前途的治疗剂,用于控制家禽的细菌感染,改善肠道健康和整体动物福利.
相关概念视频
Digestive Functions of the Large Intestine
2.2K
The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
2.2K
Restorative Care
2.4K
Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
2.4K
Balancing Redox Equations
61.9K
Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
61.9K
Dietary Connections
61.7K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
61.7K
Anatomy of the Intestines
87.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.3K
Proteins: Dietary Sources and Requirements
1.7K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.7K


