益生菌在患有刺激性肠综合征的儿童中的有效性和安全性:系统性审查和元分析
Marisa Piccirillo1,2, Erika Renzi3, Corrado De Vito3
1Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.
益生菌补充剂显著降低了患有刺激性肠综合征 (IBS) 的儿童的腹痛. 它们还能使腹或便秘患者的肠道习惯正常化,为儿科IBS提供了有希望的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 刺激性肠综合征 (IBS) 是一种肠-大脑相互作用障碍,原因尚不清楚.
- 大脑-肠-微生物群轴对于IBS管理至关重要.
- 益生菌有望改善儿童和成人IBS症状.
研究的目的:
- 系统地审查和元分析随机对照试验 (RCT).
- 评估益生菌补充剂在儿科IBS患者的疗效.
- 评估对腹部疼痛和便一致性的影响.
主要方法:
- 系统性审查和RCT的元分析.
- 在Scopus,PubMed和Cochrane图书馆搜索到2025年2月.
- 包括6个RCT,其中604名儿科参与者被诊断患有IBS (罗马III/IV标准).
主要成果:
- 益生菌补充剂显著减少了儿科IBS患者的腹痛 (SMD -0.95).
- 分析显示,在腹或便秘的患者中,益生菌使便的一致性正常化 (OR 2.17).
- 与安慰剂相比,益生菌改善了关键的IBS症状.
结论:
- 益生菌补充剂在减少儿科IBS的腹痛方面是有效的.
- 益生菌显著使IBS相关的腹或便秘的儿童的肠道习惯正常化.
- 这一元分析支持益生菌作为儿科IBS的治疗选择.
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