追踪等离子体介导的mcr基因的全球传播动态:基因组流行病学分析
Jinzhao Long1, Xin Wang1, Mengyue Liu1
1Department of Epidemiology, College of Public Health, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450001, China.
Microorganisms
|January 28, 2026
概括
塑体上的移动胆固醇抗性 (mcr) 基因通过不同的传播模式在全球范围内传播. 现在IncX4,IncI2和IncHI2/HI2A等质体在宿主和区域之间稳定,需要加强监测和干预.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 移动胆固醇抗性 (mcr) 基因对控制多药性耐药性格拉姆阴性病原体构成重大威胁.
- 了解携带mcr的等离子体的流行病学对于限制它们在人类,动物和环境中传播至关重要.
研究的目的:
- 为了分析mcr携带的等离子体的全球时空动态.
- 为了确定关键等离子体谱系的传播模式和起源.
主要方法:
- 从1995年到目前为止,分析了5549个携带mcr的等离子体.
- 质粒和微型遗传环境的序列相似性聚类.
- 分子约会和植物遗传学分析.
主要成果:
- 确定了四个不同的mcr载体等离子体传播模式时期,其中IncHI2/HI2A,IncI2和IncX4等离子体具有不同的优势.
- 通过横向基因转移和克隆扩张,在不同的宿主和区域中建立了IncX4,IncI2和IncHI2 / HI2A等离子体的稳定分布.
- 确定了79个交叉属,43个大肠杆菌内部和10个大肠杆菌内部的传染单位.
- 在动物宿主中追溯IncX4等离子体的起源到1990年,并突出了IncP1等离子体作为mcr-1和mcr-3在东南亚传播的关键载体.
结论:
- 携带mcr的等离子体已经发展出复杂的全球传输网络.
- 迫切需要协调干预和加强监测,以缓解等离子体介导的mcr基因的传播.
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