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患有急性淋巴细胞白血病和口腔粘膜炎的患者的口腔微生物组动力学
Ana Elizabeth Sánchez-Becerra1, Marcela Peña-Rodríguez2, Alejandra Natali Vega-Magaña3
1Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Microorganisms
|January 28, 2026
概括
急性淋巴细胞白血病 (ALL) 的化疗改变了口腔微生物组,可能预测口腔粘膜炎 (OM) 的发展. 患有ALL儿童的IL-6和口腔功能失调升高可能在治疗期间预示着OM早期风险.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 急性淋巴细胞白血病 (ALL) 治疗,包括化疗 (CTX),显著影响口腔微生物群.
- 化疗诱导的口腔粘膜炎 (OM) 是儿科ALL患者常见的和使人虚弱的副作用.
- 了解口腔微生物组的动态和宿主反应对于管理OM至关重要.
研究的目的:
- 在CTX期间调查儿科ALL患者的口腔微生物组变化和唾液细胞因子概况.
- 为了比较患有OM和没有OM的患者之间的这些变化.
- 为了确定潜在的早期生物标志物对OM发展.
主要方法:
- 对32名接受CTX的儿科ALL患者进行了长度研究.
- 在基线,第14天和第21天采集口腔冲洗和唾液样本.
- 用于微生物组分析的16S rRNA测序和用于唾液细胞因子 (包括IL-6) 的Luminex测定.
主要成果:
- 到第14天,观察到显著的口腔微生物组变化,特别是在患有OM的患者中.
- OM的发展与增加的α多样性,机会性种群和升高的IL-6水平有关.
- 没有OM的患者保持了更稳定的口腔微生物组成.
结论:
- 时间性口腔失生症和IL-6度升高可能是OM风险的早期指标.
- 这些发现表明,在接受化疗的儿科ALL患者中,有潜在的OM预测标志物.
- 基于微生物组和细胞因子配置的有针对性的干预措施可以减轻OM的严重程度.
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