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Updated: Jan 29, 2026

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Biology of Microbial Communities - Interview
Published on: May 28, 2007
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佛罗芬尼科尔对肠道结构,微生物群落和Penaeus vannamei中的抗生素耐药性基因的影响
Gengshen Wang1,2,3, Xinyong Shi1,2, Yi Yan1,2
1State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China.
Microorganisms
|January 28, 2026
概括
在养殖中使用佛罗芬尼科尔 (FF) 抗生素会改变肠道微生物群和肠道结构,更长时间暴露会造成更大的损害. 养殖水可能是抗生素耐药性基因 (ARG) 的关键来源.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 微生物学 微生物学
- 环境科学 环境科学
背景情况:
- 在养殖中使用抗生素的目的是控制疾病,但可以破坏宿主和环境微生物群.
- 有限有效的抗生素选择需要评估花尼科尔 (FF) 对肠健康和微生物群落的影响.
研究的目的:
- 研究FF对*Penaeus vannamei*肠道结构,微生物群落和抗生素耐药基因 (ARG) 的影响.
- 评估FF退出后健康和微生物群的恢复情况.
- 探索养殖水作为ARG储备的作用.
主要方法:
- 暴露 *Penaeus vannamei* 在5天和10天的FF中,然后在基底饮食上进行10天的恢复期.
- 在肠和养殖水中分析肠道结构,微生物组成 (16S rRNA测序) 和ARG.
主要成果:
- 施用FF导致了剂量依赖的肠损伤,治疗后逐渐恢复.
- 在肠和养殖水中观察到微生物组成和β多样性的显著变化.
- 长时间的FF暴露 (10天) 导致康复后肠道细菌的变化 (例如,减少*Rhodobacteraceae*,增加*Flavobacteriaceae*和*Vibrionaceae*).
- 与肠相比,养殖水显示出具有更高的ARG传播储备潜力.
结论:
- FF的服用时间影响了的肠道健康和微生物群组成.
- 后FF恢复是可能的,但长时间暴露可能导致持续的微生物转移.
- 养殖水在水产养殖环境中ARG的传播中发挥着重要作用.
- 调查结果强调需要仔细评估FF使用时间,并强调过度使用在养殖中的风险.
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