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使用不同提取方法获得的Pinus koraiensis叶油的比较生物活性和脂肪酸成分
Jung-Eun Kim1, Kyung Tae Jang2, Leeseon An1
1Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dondaemun-gu, Seoul 02447, Republic of Korea.
Life (Basel, Switzerland)
|January 28, 2026
概括
来自韩国松叶的超临界CO2提取油 (SPO) 与精油 (EPO) 相比显示出增强的生物活性. SPO表现出更广泛的抗癌,抗氧化和抗炎作用,脂肪酸多样性更大,支持其作为功能成分的使用.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 营养保健品 营养保健品
背景情况:
- 松树 (Pinus koraiensis) 叶子具有多种生物活性,包括抗癌,抗肥胖,抗糖尿病和抗高脂性质.
- *精油 (EPO) 和超临界CO2提取油 (SPO) 是植物材料的常见提取物,在化学成分和生物活性方面可能有所不同.
研究的目的:
- * 为了比较物理化学特征,生物活性 (抗菌,抗癌,抗炎,抗氧化剂),以及来自P. koraiensis的EPO和SPO脂肪酸概况.
- * 评估这些提取物作为功能性食品或药物成分的潜力.
主要方法:
- *使用精油蒸和超临界CO2提取来提取油.
- * 物理化学特征.
- * 抗菌检测对 * 菌株突变菌 * 和 * 白菌.
- *在HaCaT和THP-1细胞中抗氧化剂 (ROS抑制) 和抗炎症 (TNF-α,IL-6) 作用的体外测定.
- *细胞毒性测定与人类癌症细胞系组进行对比.
- * 气色谱-质谱 (GC-MS) 用于脂肪酸分析.
主要成果:
- *SPO对*S. mutans*表现出更强的抗菌活性,而EPO对*C. albicans*更有效.
- * SPO在细胞系中表现出优异的抑制LPS诱导的ROS和减弱的TNF-α和IL-6上调.
- *SPO对非小细胞肺癌,前列腺癌和结肠癌细胞系产生更大的细胞毒性.
- *GC-MS分析显示,与EPO相比,SPO中的脂肪酸多样性更大 (16 种脂肪酸,10 种唯一)
- * Pentadecenoic 酸在两种油中都是丰富的,而 linolelaidic 酸是EPO的独特特征.
结论:
- *与EPO相比,SPO具有更广泛的生物活性,包括增强的抗微生物,抗癌,抗炎和抗氧化作用.
- *SPO表现出更丰富,更多样化的脂肪酸组成.
- *由于其优越的生物活性和组成特征,SPO显示出作为功能性食品成分或药物剂的巨大潜力.
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