在脊髓损伤后,混合12个月外骨训练与皮肤外皮刺激
Jakob N Deitrich1, Muhammad Uzair Rehman1,2, Robert Trainer3,4
1Spinal Cord Injury and Disorders Center, Richmond VA Medical Center, Richmond, VA 23249, USA.
Life (Basel, Switzerland)
|January 28, 2026
概括
混合外骨架辅助步行 (EAW) 与脊髓外周刺激 (SCES) 结合,改善了脊髓损伤 (SCI) 患者的步行速度和距离. 这种综合方法增强了SCI恢复的康复潜力.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 外骨架辅助行走 (EAW) 在慢性脊髓损伤 (SCI) 中增强了行走和独立性.
- 脊髓外周刺激 (SCES) 显示出有望促进SCI的运动器恢复.
- 结合EAW和SCES可能为运动功能增强提供协同效益.
研究的目的:
- 调查12个月混合方法的有效性,将EAW与SCES结合起来,以改善慢性运动完整SCI的个体的运动性能.
- 为了比较EAW与SCES对EAW单独的影响,并评估抵抗训练和延迟的SCES的影响.
主要方法:
- 四名患有慢性运动完整SCI的男性接受了皮肤穿SCES植入.
- 参与者接受了一项为期12个月的干预,涉及EAW与SCES,有不同阶段的辅助模式 (固定与自适应) 以及包括抵抗训练.
- 外骨性能数据 (步骤,距离,速度,辅助水平) 通过Ekso Pulse平台每周收集.
主要成果:
- 参与者完成了48周学习时间的85%,EAW平均每次活动时间为46分钟.
- 与固定模式相比,在适应式辅助模式下观察到每分钟步数,EAW距离和速度的增加.
- 适应模式与外骨架辅助水平的降低有关.
结论:
- 经过12个月的EAW和SCES混合干预,步行速度和距离得到了显著的改善,特别是在适应性辅助下.
- 这些发现支持外骨与神经调节技术 (如SCES) 的整合,以加强SCI康复.
- 这种混合方法为未来的治疗策略提供了潜力,旨在最大限度地提高SCI后的运动恢复.
相关概念视频
01:26Spinal Cord
1.8K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
1.8K
01:54The Spinal Cord
31.7K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.7K
01:10Spinal Cord: Information Processing
3.4K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.4K
01:15Spinal Cord: Gross Anatomy
5.7K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.7K
01:16Spinal Cord: Cross-sectional Anatomy
4.6K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.6K
02:29Hybrid Zones
21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K