在STEMI患者的无回流现象中Apelin-36的预测值
Xhevdet Krasniqi1,2, Xhevat Jakupi1, Josip Vincelj3
1Department of Internal Medicine, Medical Faculty, University of Prishtina "Hasan Prishtina", 10000 Prishtina, Kosovo.
Life (Basel, Switzerland)
|January 28, 2026
概括
血清阿佩林-36水平与ST段升高心肌梗塞 (STEMI) 患者的no-reflow现象有关. 截止值为0.58 ng/mL可以识别患有初级皮肤穿透冠状动脉干预后不回流风险增加的患者.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 在ST段升高心肌梗塞 (STEMI) 中,阿佩林被上调,并提供针对缺血-再输液损伤 (IRI) 的心脏保护.
- 研究STEMI患者的血清阿佩林-36水平对于了解它在无反流现象中的作用至关重要.
研究的目的:
- 检查STEMI患者的血清阿佩林-36水平.
- 确定血清阿佩林-36水平与初级皮肤冠状动脉干预 (pPCI) 后不回流现象发生率之间的关系.
主要方法:
- 在症状发作12小时内接受pPCI的161名STEMI患者被纳入.
- 测量了血清阿佩林-36,热血素T和其他生物化学标记物.
- 进行心声扫描,并根据阿佩林-36水平对患者进行分组.
主要成果:
- 在apelin-36水平>0.58 ng/mL (47.82%) 的患者中,与≤0.58 ng/mL (25.21%) 的患者相比,观察到无反流现象的发生率更高.
- 在阿佩林-36水平和根西尼分数之间发现了正相关性.
- 鉴定出阿佩林-36和糖尿病是无回流的显著预测因素,诊断截止值为0.58 ng/mL (AUC = 0.77).
结论:
- 血清阿佩林-36水平与STEMI患者的无回流现象显著相关.
- 0.58 ng/mL的入院阿佩林-36截止值可以帮助识别STEMI患者有较高的无反流/再输血损伤风险.
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