使用MACRO技术制造的基于氨酸的软组织填充剂组合的安全概况:临床证据的系统审查
Konstantin Frank1, Said Hilton2, Martina Kerscher3
1Center of Plastic, Aesthetic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Life (Basel, Switzerland)
|January 28, 2026
概括
使用MACRO核心技术的氨酸填充剂显示出强大的安全性. 大多数不良事件都是轻微的,注射相关的,并迅速消失,支持它们在美学皮肤学中的使用.
科学领域:
- 皮肤病学 皮肤病学
- 审美医学是一种美学医学.
- 生物材料科学 生物材料科学
背景情况:
- 氨酸 (HA) 填充剂在美学皮肤学中很受欢迎,因为它们具有有利的特性.
- 尽管安全记录良好,但与HA填充剂相关的不良事件 (AE) 需要进行持续的安全评估.
研究的目的:
- 审查使用MACRO (MAtrix CROsslinking) 核心技术的HA填充剂的安全性.
- 评估与saypha和传统Princess HA填充剂产品相关的短期和长期不良事件.
主要方法:
- 使用PubMed进行了系统的文献搜索.
- 包括评估面部美学HA填充剂使用安全结果的前性临床试验.
- 包括947名患者的11项研究符合纳入标准.
主要成果:
- 常见的短期副作用包括轻度至中度的胀,疼痛和伤,在两周内消失.
- 严重或严重的与治疗相关的事件很少发生;在所有研究中只报告了一个.
- 长期的副作用,如延迟结节或炎症反应是罕见的和轻微的,没有观察到颗粒瘤,过敏或血管并发症.
结论:
- 使用MACRO核心技术的saypha HA填充剂组合显示出可预测和强大的安全性.
- 安全结果在不同配方以及传统产品和当前产品之间是一致的.
- 大多数AE似乎与注射创伤有关,而不是填充材料本身,支持其临床使用.
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