扩散张力成像生物标志物用于预测脑外科手术中的神经结果:系统性审查
Noa Ben Dor1,2, Giovanni Sighinolfi3, Vittoria Rosetti2
1Department of Neurosurgery, IRCCS Institute of Neurological Sciences of Bologna, 40139 Bologna, Italy.
Life (Basel, Switzerland)
|January 28, 2026
概括
定量扩散张力成像 (DTI) 度量表现出预测大脑手术后运动和语言恢复的前景. 然而,需要更多的研究来确定这些先进的成像技术的普遍预后值.
科学领域:
- 神经外科 神经外科
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 扩散张力成像 (DTI) 路谱对于神经外科规划至关重要.
- 对术后功能结果的定量DTI指标的预后价值尚未得到充分确立.
研究的目的:
- 系统地审查证据,将定量DTI测量与术后的运动,语言和认知结果联系起来.
- 综合关于DTI在神经外科手术中的预后意义的发现.
主要方法:
- 基于PRISMA的PubMed和其他索引来源的系统审查 (2005年1月至2025年12月).
- 包括37项研究,主要是单中心研究,重点研究质瘤手术.
主要成果:
- 皮质脊柱管的完整性降低和不良的扩散变化与运动缺陷相关.
- 背部语言通路的完整性预测了较轻的失语;腹部通路的改变与词汇语义缺陷有关.
- 对于认知和步态结果的证据有限,涉及协会,边缘和状通路.
结论:
- 定量DTI提供了临床相关的标记器,用于管道中断和网络重塑后手术.
- 方法的异质性和有限的验证阻碍了对DTI指标的普遍预后值的建立.
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