由Laurus nobilis引起的草药引起的肝损伤:使用更新的RUCAM评估因果关系的病例
Mihnea Soare1, Sabina-Florina Călugăr-Șolea1, Ciprian Brisc1,2
1Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Life (Basel, Switzerland)
|January 28, 2026
概括
咖啡叶茶的消费可能会导致肝损伤 (HILI). 一个案例研究显示,一个患者的肝酶升高,在停止海湾叶输液后得到解决,突出了潜在的草药诱导的肝损伤.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
- 内部医学 内部医学
背景情况:
- 肝细胞损伤综合征有多种不同的原因,需要详细的病史和准临床评估来准确诊断.
- 肝转氨酶水平升高表明肝脏受损,需要进行调查以排除各种病因因素.
研究的目的:
- 呈现一种可能与食用草药输液有关的肝细胞损伤病例.
- 突出详细的病史在识别肝损伤的不常见原因,如草药诱导肝损伤 (HILI) 的重要性.
主要方法:
- 获得了全面的病史,重点关注患者的饮食习惯和草药产品消费.
- 进行了生物化学测试,免疫学测试和肝活检,以评估肝功能并确定损伤的病因.
- 更新的罗塞尔Uclaf因果关系评估方法 (RUCAM) 尺度被用于评估草药诱导的肝损伤的可能性.
主要成果:
- 一名55岁的女性患者呈现肝转氨酶水平显著升高 (AST=196 U/L,ALT=357 U/L),没有先前的肝病理.
- 组织病理学检查表明有毒肝炎,RUCAM尺度分配了8分,表明可能来自海湾叶茶的HILI.
- 停止喝海湾叶茶导致肝功能临床和生化改善.
结论:
- 通常食用的草,如海湾叶 (Laurus nobilis),可以具有肝毒性潜力,特别是当用作缩输液时.
- 关于草药产品使用的详细患者病史对于诊断和管理不明原因肝损伤病例至关重要.
- 这一案例强调了临床医生需要提高对草药诱导的肝损伤的认识.
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