在孕激素主导的卵巢刺激 (PPOS) 协议中同时使用莱特:在体外受精患者的系统性审查
Raffaella Di Girolamo1, Maria Giuseppina Trinchillo1, Luigi Vigilante1
1Department of Public Health, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
Journal of clinical medicine
|January 28, 2026
概括
将莱特醇添加到标准的GnRH激素激素长期协议 (PPOS) 中,可能会改善IVF患者的卵细胞产量,特别是正常和不良反应者. 然而,疗效有所不同,在PCOS患者中没有显示任何益处.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 在试管婴儿中,标准的淋巴激素释放激素agonist长协议 (PPOS) 被广泛使用.
- 调查PPOS的修改,例如与莱特醇 (PPOS + LE) 联合使用,对于优化卵巢刺激结果至关重要.
研究的目的:
- 系统地分析和综合现有文献,将PPOS + LE协议与IVF患者的标准PPOS进行比较.
- 为了评估莱特醇联合给药对卵巢刺激和怀孕结果的影响.
主要方法:
- 在主要数据库 (MEDLINE,Scopus,EMBASE,科学引用索引) 进行系统的文献搜索.
- 包括五项回顾性研究进行分析.
- 使用纽卡斯尔-太华尺度进行质量评估.
- 主要结局:卵细胞的检索和成熟;次要结局:荷尔蒙水平和怀孕率.
主要成果:
- 在正常和不良反应者中,PPOS + LE显示了增加卵细胞检索和成熟的潜力 (POSEIDON组4).
- 在患有多囊性卵巢综合征 (PCOS) 或POSEIDON组3的患者中没有观察到显著的益处.
- 可变的疗效表明患者的特征会影响治疗反应.
结论:
- 在PPOS中加入莱特可能会抵消垂体抑制,在特定的患者群体中可能会增加LH水平和卵细胞产量.
- PPOS + LE的好处不是普遍的,似乎取决于患者的表型 (例如,PCOS).
- 为了验证这些发现,需要进行进一步的前性研究,因为目前的数据具有追溯性.
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