贫血作为静脉血栓栓塞的强大且未被认可的驱动因素:系统性审查
Ghaith K Mansour1, Walaa A Alshahrani2, Lama Alfehaid2,3,4
1Department of Pharmaceutical Sciences, College of Pharmacy, Alfaisal University, Riyadh 11533, Saudi Arabia.
Journal of clinical medicine
|January 28, 2026
概括
营养缺乏症贫血,特别是铁缺乏症,与静脉血栓栓塞 (VTE) 风险增加和不良结果有关. 需要更多的研究来确认特定缺陷的因果关系,并将贫血查纳入VTE风险模型.
科学领域:
- 血液学 血液学 血液学
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 营养缺乏贫血 (铁,维生素B12,叶酸) 在全球普遍存在.
- 贫血越来越多地被认为是静脉血栓塞栓症 (VTE) 的贡献者.
- 现有的数据表明,潜在的机制将贫血与血栓形成联系起来,但缺乏集中合成.
研究的目的:
- 系统地审查和综合临床和遗传证据,将营养缺乏症贫血与VTE联系起来.
- 评估各种研究设计中贫血和VTE结果之间的关联.
主要方法:
- 在PubMed和Cochrane图书馆进行系统的文献搜索,截至2025年9月.
- 包括观察性研究,病例报告,病例系列和孟德尔随机化 (MR) 分析.
- 使用纽卡斯尔-太华尺度,JBI检查清单和ROB-MR进行质量评估;注册在PROSPERO.
主要成果:
- 七项研究符合纳入标准;观察性研究一致将贫血与不良VTE结局联系起来.
- 较低的血红蛋白与肺栓塞的较高死亡率以及住院患者的风险增加相关.
- 缺铁性贫血显示VTE的几率增加;MR表明潜在的因果关系与异常部位的血栓形成.
结论:
- 贫血,特别是缺铁性贫血和低血红蛋白,是与高静脉瘤风险和不良结果相关的未被认可的因素.
- 对维生素B12和叶酸缺乏性贫血的证据有限.
- 需要进一步的前性研究来确认因果关系,并指导贫血评估在VTE风险模型中的临床整合.
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