听力损失在神经脊髓炎光学谱系障碍:病例报告和系统审查
Stefania Kalampokini1, Effrosyni Koutsouraki1, George Psillas2
11st Department of Neurology, AHEPA University Hospital, Aristotle University, 54636 Thessaloniki, Greece.
Journal of clinical medicine
|January 28, 2026
概括
突发性听力损失在神经omyelitis光学谱障碍 (NMOSD) 中很罕见. 这项研究突出了一个案例,并审查了文献,发现听力损失可能是NMOSD早期症状,如果不被识别,会影响结果.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 突然的,非创伤性听力损失与血管/炎症状况有关.
- 听力损失是神经脊髓炎光学谱系障碍 (NMOSD) 的极为罕见的表现.
- 水-4抗体是NMOSD病原发生的关键生物标志物.
研究的目的:
- 报告一个罕见的外围听觉通路参与aquaporin-4阳性NMOSD的病例.
- 系统地审查有关NMOSD患者听力损失的现有文献.
- 阐明NMOSD中听力损失的临床表现,局部和治疗结果.
主要方法:
- 一个58岁的女性患有NMOSD,双边耳和单边耳聋的病例介绍.
- 听觉脑干反应测试以确定听觉通路损伤.
- 对MEDLINE和Scopus用于NMOSD相关听力损失病例的系统文献综述.
主要成果:
- 总共有15个病例被确定,包括目前的病例.
- 听力损失主要影响26-70岁的女性 (73.3%),通常是AQP4阳性NMOSD.
- 听力障碍可以是中央或外围的,可能伴有耳,心力衰退或吐.
结论:
- 周围听觉通路影响是NMOSD的一个罕见但显著的表现.
- 在NMOSD复发期间早期诊断和治疗听力损失对于患者的治疗结果至关重要.
- 这项研究扩大了对NMOSD作为影响听觉通路的自身免疫水素-4通道病变的理解.
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