动态免疫营养指数作为乳腺癌患者接受新辅助化疗的病理完整反应的强有力的预测指标
Emel Mutlu Ozkan1, Ibrahim Karadag2, Mevlude Inanc1
1Department of Medical Oncology Clinic, Faculty of Medicine, Erciyes University, 38280 Kayseri, Türkiye.
Journal of clinical medicine
|January 28, 2026
概括
基线和动态免疫营养生物标志物,特别是营养风险指数 (NRI) 和全球免疫营养信息指数 (ΔGINI) 的变化,在接受新辅助化疗 (NACT) 的乳腺癌患者中有效预测病理完整反应 (pCR). 这些可访问的血液标记物有助于早期识别治疗反应.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 化疗 化疗是一种化学疗法.
背景情况:
- 病理完整反应 (pCR) 是新辅助化疗 (NACT) 在乳腺癌中有效性的关键指标.
- 预测PCR的方法有限,需要可访问的早期评估工具.
- 常规血液检查中的免疫炎症和基于营养的生物标志物显示出对评估治疗反应的希望.
研究的目的:
- 评估免疫营养指数的基线和动态 (Δ) 变化,以预测乳腺癌早期患者的pCR.
- 为了确定可靠和可访问的生物标志物,以便早期预测NACT疗效.
主要方法:
- 对236名接受NACT.治疗的早期乳腺癌患者的回顾性分析.
- 对多种免疫营养指数 (PNI,ALI,HALP,SIRI,PIIV,GINI,NRI) 的基线 (B),治疗后 (A) 和 Δ 值的计算.
- 统计分析包括后勤回归和ROC分析,以评估pCR的预测性能.
主要成果:
- 在49.2%的患者中实现了pCR.
- 营养风险指数 (NRI), ΔGINI, ALI, PNI, HALP得分, ΔSIRI 和 ΔPIIV 是pCR的重要预测指标.
- NRI (AUC=0.840) 和 ΔGINI (AUC=0.807) 显示了预测pCR的最强的诊断性能.
结论:
- 基线和动态免疫营养生物标志物都可以预测乳腺癌中NACT后的pCR.
- NRI 和 ΔGINI 是最有效的预测指标,而 ΔSIRI 和 ΔPIIV 也显示出显著的关联.
- 这些低成本,易于获得的生物标志物,特别是 Δ 标志物,可以帮助早期识别响应者和个性化治疗决策.
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