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内拉尼祖马布注射对视网膜神经纤维层厚度和光盘参数的影响
Gülin Tuğba Ongun1, Ramazan Yağcı2
1Department of Ophthalmology, Antalya City Hospital, Antalya 07230, Turkey.
Journal of clinical medicine
|January 28, 2026
概括
内拉尼比祖马布在糖尿病黄斑 (DME) 和视网膜静脉封闭 (RVO) 的患者中降低了视网膜神经纤维层 (RNFL) 厚度,但在与年龄相关的黄斑变性 (AMD) 病例中没有. 光学连贯断层扫描 (OCT) 检测到稀释,而海德堡视网膜断层扫描仪III (HRT-3) 没有.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理疗法 药理疗法 药理疗法
背景情况:
- 与年龄相关的黄斑变性 (AMD) 继发的黄斑,糖尿病黄斑 (DME) 和视网膜静脉封闭 (RVO) 是导致视力丧失的主要原因.
- 内抗血管内皮生长因子 (抗VEGF) 药物,如拉尼比祖马布,是这些疾病的标准治疗方法.
- 拉尼比祖马布对视网膜神经纤维层 (RNFL) 和光盘参数的影响需要进一步研究.
研究的目的:
- 评估内拉尼比祖马布对DME,AMD和RVO患者的RNFL厚度和光盘参数的影响.
- 为了比较不同斑点水病因之间的RNFL和光盘指标的变化.
- 评估光学相干断层扫描 (OCT) 和海德堡视网膜断层扫描仪III (HRT-3) 的评估结果之间的一致性.
主要方法:
- 对60名接受静脉内拉尼比祖马布 (0.5毫克) 治疗黄斑的患者进行了回顾性分析.
- 数据收集包括最佳校正的视敏度 (BCVA),眼内压力 (IOP),RNFL厚度和光盘参数.
- 在基线和多个时间点在注射后6个月内使用OCT和HRT-3进行了测量.
主要成果:
- 在所有患者组中观察到BCVA的显著改善.
- 平均RNFL厚度显示,DME和RVO组的显著减少 (分别p=0.0001和p=0.043) 被测量为OCT.
- HRT-3没有检测到显著的RNFL稀释,光盘参数显示出可变的,疾病特异性的变化.
结论:
- 室内拉尼比祖马布治疗与DME和RVO患者在六个月内RNFL稀释相关,可通过OCT检测.
- HRT-3没有检测到显著的RNFL变化,光盘变化不一致和疾病特异.
- 这些发现仅限于非眼眼睛;需要进一步的前性研究来了解对视神经的长期影响.
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