基于医院的罗马尼亚队列中的肝病负担和进展的回顾性分析,使用综合横截面和纵向数据 (2019-2023)
Alina Dumitrache Păunescu1,2, Nicoleta Anca Șuțan2, Diana Ionela Popescu Stegarus3
1Doctoral School of University of Medicine and Pharmacy of Craiova, Petru-Rareș Street no. 2, 200349 Craiova, Romania.
Journal of clinical medicine
|January 28, 2026
概括
这项关于罗马尼亚慢性肝病的研究发现,病因,性别和年龄显著影响患者的治疗结果和医疗保健使用. 个性化,由病因驱动和适合性别的管理对于更好的患者护理至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 慢性肝病 (CLD) 包含各种病因,包括病毒性肝炎,酒和非酒精性脂肪肝.
- 了解不同类型的CLD的人口变化和临床结果对于有效的医疗保健规划至关重要.
- 罗马尼亚医疗保健数据为CLD流行病学和管理挑战提供了独特的视角.
研究的目的:
- 为了分析人口统计特征,临床并发症和医疗保健利用在一个大型的罗马尼亚队列的CLD患者.
- 在主要的CLD病因方面比较患者资料和结果:慢性肝炎C (CHC),与酒精有关的肝炎 (ALH),与酒精有关的肝硬化 (ALC) 和非酒精性肝硬化 (NALC).
- 确定影响CLD患者住院模式和并发症风险的关键决定因素.
主要方法:
- 在罗马尼亚,2019年至2023年期间治疗的2359名CLD患者的回顾性分析.
- 收集的数据包括人口统计,临床结果和住院记录.
- 统计分析涉及描述性统计,回归建模和使用IBM SPSS 27.0.1.1. 的集群.
主要成果:
- 观察到显著的年龄差异:CHC患者最老 (平均67.5岁),ALH患者最年轻 (56.0岁). 慢性心血管疾病的患病率与年龄的增加有很强的相关性 (p < 0.001).
- 性别分布因病因而异:在CHC中60-70%的女性,在ALH中超过85%的男性和在ALC中78%的男性.
- 平均住院时间随着时间的推移而减少,但对于肝硬化患者来说最长 (NALC: 16.37天,ALC: 17.66天). 病因学是住院时间的主要预测因素. 门高血压 (54.3%) 是最常见的并发症,男性患上更严重的并发症,如炎 (38.3%) 和门高血压 (66.8%).
结论:
- 罗马尼亚的患者表现和结果受到CLD病因,患者性别和年龄的显著影响.
- 显而易见的流行病学模式出现了:女性在CHC中占主导地位,男性在与酒精有关的肝病中占主导地位,以及非酒精性肝硬化症的具体趋势.
- 研究结果强调,需要针对慢性肝病制定个性化,病因驱动和性别定制的临床管理策略.
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