在使用血清炎症标记物治疗牛皮患者的主要自动血疗 (MAH) 的评估
Seçil Soylu1, Nazlı Şensoy2, Nurhan Doğan3
1Department of Dermatology and Venereology, Division of Internal Medical Sciences, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, Türkiye.
Journal of clinical medicine
|January 28, 2026
概括
臭氧自动血疗显示出对牛皮的临床有效性,降低了疾病严重程度和炎症标志物,如高灵敏度C反应蛋白 (Hs-CRP) 和酸结合Ig类莱克-14 (Siglec-14) 等. 这种治疗可能为管理这种慢性皮肤疾病提供了一个新的选择.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 医学生物标志物 医学生物标志物
背景情况:
- 牛皮是一种慢性,炎症性,全身性皮肤疾病.
- 目前的治疗方法包括局部和全身药物,但臭氧治疗是一种新兴的选择.
- 关于臭氧疗法在牛皮的疗效和机制的发表数据有限.
研究的目的:
- 为了评估臭氧自动血疗在牛皮患者的临床有效性.
- 评估与炎症和牛皮相关的血清生物标志物的变化.
- 探索炎症在臭氧治疗作用机制中的作用.
主要方法:
- 一项涉及26名牛皮患者和19名健康对照者的研究.
- 牛皮的严重程度使用牛皮区域和严重程度指数 (PASI) 评分进行评估.
- 测量了瘤亡因子α (TNF-α),介质素1-β (IL-1β),高灵敏性C反应蛋白 (Hs-CRP),酸和酸结合Ig类乐-14 (Siglec-14) 的血清水平.
主要成果:
- 臭氧自血疗法显著降低了牛皮患者的PASI得分 (p < 0.005).
- 在治疗后的IL-1β,酸和Siglec-14的血清水平在健康人群中高于牛皮患者.
- 治疗后HS-CRP和Siglec-14水平下降,轻度牛皮患者的HS-CRP和Siglec-14的轻度和中度至重度组显著减少 (p <0.05).
结论:
- 臭氧自动血液疗法在治疗牛皮方面显示出临床疗效.
- 炎症在牛皮臭氧治疗的作用机制中起作用.
- 炎症标志物可以用于评估臭氧治疗在牛皮治疗中的有效性.
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