疼痛相关疾病的神经生理学,放射学和分子生物标志物:一个总体审查
Dmitriy Viderman1,2, Sultan Kalikanov1, Diyara Mukazhan1
1Department of Surgery, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.
Journal of clinical medicine
|January 28, 2026
概括
没有单一的疼痛生物标志物被临床验证为慢性疼痛,但炎症标志物和神经成像显示有前途. 未来的研究需要标准化的协议和多生物标志物面板,以更好地评估疼痛.
科学领域:
- 生物标志物 生物标志物
- 疼痛研究 疼痛研究
- 系统审查是系统的审查.
背景情况:
- 慢性疼痛对全球的健康和经济造成重大负担.
- 目前的疼痛评估和诊断方法需要改进.
- 生物标志物被建议用于增强疼痛管理,强度评估和诊断.
研究的目的:
- 综合所有可用的疼痛生物标志物的临床实用性的证据.
- 评估有关疼痛生物标志物的现有系统审查的质量.
- 为未来的研究和临床应用确定有前途的生物标记物类.
主要方法:
- 总体审查方法.
- 在PubMed,Scopus和Cochrane图书馆进行系统搜索.
- 包括关于疼痛生物标志物的系统审查和元分析.
- 使用AMSTAR-2工具进行质量评估.
- 发现的叙述综合.发现的叙述综合.
主要成果:
- 包括49个系统性审查和元分析,大多数质量低或非常低.
- 炎症生物标志物 (CRP,IL-6,TNF-α) 与慢性肌肉骨疼痛有着一致的关联.
- 神经成像和EEG测量表明了中枢神经系统的变化.
- 蛋白质组组显示出纤维肌痛诊断的潜力,但缺乏验证.
- 对遗传,激素,代谢和神经化学生物标志物的证据是不一致的.
结论:
- 目前没有单一的生物标志物被临床验证用于慢性疼痛.
- 炎症和神经成像生物标志物显示出疼痛评估的潜力.
- 未来的研究应该专注于高质量的纵向研究,标准化协议和多维生物标志物面板.
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