"反向"双刺激具有相似的效率,但效率更高,比两种常规的卵泡期刺激在接受体外受精的低响应者中具有相似的效率,但效率更高
Andrea Roberto Carosso1, Chiara Benedetto1, Bernadette Evangelisti1
1Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, Italy.
Journal of clinical medicine
|January 28, 2026
概括
反向双刺激 (R-DS) 允许新鲜的胚胎转移,并显著缩短了对反应不良患者怀孕的时间. 这种方法可与两个卵泡阶段控制的卵巢刺激 (2FP-COS) 周期进行卵细胞检索和活产率相比较.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
背景情况:
- 在受控卵巢刺激 (COS) 中的双刺激产生了更多的卵细胞,但排除了新鲜胚胎转移 (ET).
- 反向双刺激 (R-DS) 旨在通过改变刺激序列来实现新的ET.
- 本研究将R-DS与两个连续的卵泡阶段COS (2FP-COS) 周期进行比较.
研究的目的:
- 为了研究R-DS与2FP-COS相比,R-DS在反应不佳者中的生殖结果.
- 评估R-DS是否可以缩短怀孕的时间.
主要方法:
- 追溯研究146个低响应者 (45个R-DS,101个2FP-COS).
- 在R-DS中,第一次COS是在排卵后5天进行的,第二次是在卵细胞检索后5天进行的.
- 主要结局是怀孕的时间;次要结局包括卵细胞检索和活产率.
主要成果:
- R-DS显示了可比的刺激长度,卵细胞检索和芽细胞形成与卵泡阶段的COS.
- 在R-DS.中,在排卵触发时,孕激素水平保持在<1.0 ng/mL.
- R-DS导致怀孕的时间显著缩短 (52.9天) 与2FP-COS (103.2天) 相比.
结论:
- 在卵细胞检索和累积活产率方面,R-DS与2FP-COS不逊色.
- R-DS 促进了即时的新鲜胚胎转移.
- R-DS显著缩短了怀孕的时间,这对于反应不佳的人来说是一个关键的好处.
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