FIB-4指数与结性脊柱炎患者的QTc间隔独立相关
Elif Ergül1, Hüseyin Durak1, Mustafa Çetin1
1Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdoğan University, 53020 Rize, Türkiye.
Journal of clinical medicine
|January 28, 2026
概括
在性脊柱炎 (AS) 患者中,非侵入性纤维化标志物FIB-4指数独立与延长的QTc间隔相关. 这表明FIB-4可能有助于AS的心血管风险评估.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 生物标志物 生物标志物
背景情况:
- 延长QTc间隔增加了心室节律失常和心脏突然死亡的风险.
- 结节性脊柱炎 (AS) 涉及全身炎症和代谢变化,但其与QTc和纤维化标志物的联系尚不清楚.
研究的目的:
- 研究AS患者的FIB-4指数和QTc间隔之间的关联.
主要方法:
- 分析了82名AS患者的人口统计数据,并发症和实验室结果.
- 根据血液检查和心电图,计算/测量FIB-4指数和QTc间隔.
- 相关性和多变量回归分析确定了QTc的预测因素.
主要成果:
- 在AS患者中,FIB-4指数与QTc间隔有显著的关联.
- 多变量分析证实性别和FIB-4指数是QTc的独立预测指标.
- 年龄,BMI,高血压,高脂血症和心血管药物使用也与QTc相关.
结论:
- 在AS患者中,FIB-4指数与QTc间隔独立相关.
- 像FIB-4这样的非侵入性纤维化标志物可能会增加AS中的心血管风险分层.
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