在膝关节骨关节炎患者的疼痛教育和炼计划中添加皮肤电神经刺激的可行性和初步影响:试点随机对照试验
Leonardo Rodríguez-Lagos1, Alberto Arribas-Romano1,2, Sofía Laguarta-Val1,2
1Cognitive Neuroscience, Pain and Rehabilitation Research Group (NECODOR), Faculty of Health Sciences, Rey Juan Carlos University (https://ror.org/01v5cv687), 28922 Alcorcón, Spain.
Journal of clinical medicine
|January 28, 2026
概括
将皮穿式电神经刺激 (PENS) 添加到膝关节骨关节炎 (KOA) 的多式方案中没有显示出比假或控制电刺激的额外好处. 该研究发现,结合方法是可行的,对于未来的试验是安全的.
科学领域:
- 疼痛管理 疼痛管理
- 神经调节是一种神经调节.
- 骨关节炎研究 骨关节炎研究
背景情况:
- 膝关节关节炎 (KOA) 显著影响功能和生活质量.
- 结合疼痛教育和运动的多模式方法是KOA的标准护理.
- 研究新的辅助疗法,如皮肤电神经刺激 (PENS),对于改善KOA管理至关重要.
研究的目的:
- 评估添加PENS到KOA的疼痛教育和炼计划的初步影响.
- 为了比较PENS与控制的穿皮电神经刺激 (TENS) 和假PENS.
- 评估KOA患者的可行性,安全性和令人眼花乱的成功.
主要方法:
- 30名患有KOA的患者随机分为PENS,对照TENS或假PENS组.
- 所有组都接受了为期12周的疼痛教育和结构化炼计划.
- 主要结局包括WOMAC,VAS,CPGS,PPT,CPM和TSP;次要结局是心理变量.
主要成果:
- 随着时间的推移,在整个样本中观察到VAS,CPGS,WOMAC,CPM和TSP的显著改善.
- 没有统计学意义上的群体时间相互作用表明干预措施之间的差异效应.
- 可行性结果是有利的,具有高的保留,坚持和最小的不良事件.
结论:
- 将PENS添加到KOA的多式联络程序中,除了程序本身和模拟/控制刺激之外,没有提供额外的好处.
- 在这项探索性试验中,发现PENS干预是可行的,安全的,并且足够盲目的.
- 结果支持进行更大规模的最终试验的可能性,以进一步调查KOA的PENS.
相关概念视频
Pilot and Numeric Relaying
489
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
489
Pharmacodynamics in Geriatric Patients: Effects of Age
202
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
202
Knee Joint
3.2K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.2K
Clinical Trials: Overview
4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
Trial and Error and Algorithm
403
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
403
Clinical Trials
10.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.4K


