普雷塞普辛在区分恶性与良性宫淋巴细胞瘤方面优于传统的炎症标志物
Orhan Tunç1, Mustafa Örkmez2, Berkay Güzel3
1Department of Otorhinolaryngology, Gaziantep University Faculty of Medicine, 27310 Gaziantep, Türkiye.
Journal of clinical medicine
|January 28, 2026
概括
普雷塞普辛在诊断宫淋巴腺病症方面表现有前途,在识别恶性瘤方面表现优于CRP和ESR等传统标志物. 这种生物标志物可以帮助指导活检决策,并减少对良性疾病的不必要手术.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 宫淋巴腺病的诊断往往依赖于侵入性手术.
- 区分良性和恶性病因需要准确的生物标志物.
- 传统的炎症标志物在特异性上有局限性.
研究的目的:
- 评估普雷塞普辛在区分良性和恶性宫淋巴腺病的诊断价值.
- 为了比较普雷塞普辛与C反应蛋白 (CRP),红细胞沉积率 (ESR) 和中性粒细胞与淋巴细胞比率 (NLR) 的性能.
主要方法:
- 在76名参与者 (52名患者,24名对照组) 中测量了血清前素,CRP,ESR和全血细胞计.
- 患者在组织病理学上被分为反应性淋巴腺病,粒状淋巴病或恶性淋巴腺病组.
- 用接收器操作特征 (ROC) 分析来评估诊断性能.
主要成果:
- 与对照组相比,患者的前素,CRP,ESR和NLR水平显著更高 (p < 0.001).
- 普雷塞普辛在恶性瘤预测方面表现出最高的诊断准确性 (AUC = 0.85),超过CRP (0.78),ESR (0.74) 和NLR (0.72).
- 一个presepsin值>210 pg/mL预测恶性瘤与82.4%的灵敏度和78.6%的特异性.
结论:
- 普雷塞普辛作为一个客观的,非侵入性的工具来评估宫淋巴腺病变.
- 它在预测恶性瘤方面的卓越性能有助于活检决策.
- 普雷塞普辛可能有助于避免对良性淋巴结核病的不必要的手术干预.
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