用免疫检查点抑制剂治疗的癌症患者的认知障碍:一个横截面研究
Betul Aktepe1, Oktay Halit Aktepe2
1Department of Psychiatry, Urla State Hospital, Ministry of Health, Izmir 35430, Türkiye.
Journal of clinical medicine
|January 28, 2026
概括
在接受免疫检查点抑制剂 (ICI) 的癌症患者中,超过一半的患者经历认知障碍. 年龄,女性性别,低学历,后期治疗,表现不佳状态和晚期疾病预测这种损伤.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- ICI的神经学副作用,特别是认知影响,尚不清楚.
- 这项研究调查了接受ICI治疗的患者的认知功能.
研究的目的:
- 为了确定接受ICI的患者认知障碍的患病率.
- 为了确定与这一群体认知缺陷相关的临床因素.
- 为潜在的查和支持性护理策略提供信息.
主要方法:
- 在两个中心对189名成年固体瘤患者进行了横截面研究,这些患者接受了ICI治疗.
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能,损伤定义为MoCA ≤ 21.
- 后勤回归模型确定了认知障碍的预测因素,考虑年龄,性别,教育,表现状况和疾病特征.
主要成果:
- 54%的患者 (102/189) 呈现认知障碍 (MoCA ≤21).
- 独立预测因素包括年龄较大 (≥65岁),女性性别,教育程度较低,后期ICI治疗,ECOG性能状态≥1和≥2转移部位.
- 对于每个已识别的预测因素,特定的赔率比率是显著的.
结论:
- 在ICI治疗的患者中,很大一部分患有客观认知缺陷.
- 建议对高风险患者子组进行系统的认知查.
- 早期识别可以促进对认知障碍的及时支持性护理干预.
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