糖尿病前期应该被归类为可治疗的疾病吗?
William E Winter1, Ishwarlal Jialal2
1Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
Journal of clinical medicine
|January 28, 2026
概括
糖尿病前期影响全球21%的人口,并显著增加2型糖尿病 (T2DM) 和心血管疾病 (CVD) 的风险. 强化生活方式干预和甲福林治疗可以有效地预防T2DM的进展.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病前期代表着一个关键的全球健康问题,影响了大约21%的世界人口.
- 它是2型糖尿病 (T2DM) 的前体,显著增加心血管疾病 (CVD) 的风险.
研究的目的:
- 为了强调全球的负担和糖尿病前期的临床意义.
- 强调早期诊断和糖尿病前期的有效管理策略的重要性.
主要方法:
- 诊断依赖于可访问和具有成本效益的血葡萄糖和/或血红蛋白A1c (HbA1c) 测量.
- 治疗侧重于强化生活方式 (ILS) 干预,包括饮食改变和定期体育活动.
- 甲胺治疗也被认为是预防T2DM进展的预防措施.
主要成果:
- 在众多全球性研究中,强化生活方式干预,包括5%的体重减轻,在减少T2DM进展方面表现出有效性.
- 甲福明已被证明是有效的预防从糖尿病前期到T2DM的过渡.
- 前糖尿病与T2DM和CVD等严重并发症有关.
结论:
- 鉴于其全球影响,诊断的可访问性,相关风险和有效的干预措施,将糖尿病前期疾病归类为一种疾病,值得指导委员会认真考虑.
- 建议针对性治疗高风险患者,包括患有葡萄糖耐受性损害 (IGT),禁食葡萄糖 (IFG) ≥110 mg/dL和/或HbA1c ≥6.0%的患者,特别是当与超重或肥胖症结合时.
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