作为扩散性鼻腔外性乳头瘤的辅助治疗方法,鼻腔外性贝瓦齐祖马布注射
Anna Penella1,2,3, Adriana Michavila1, Marta Fulla1,2,3
1Otorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Spain.
Journal of clinical medicine
|January 28, 2026
概括
针对扩散性鼻腔外性乳头瘤 (DSNEPs) 的手术后的微伤性bevacizumab注射是可行的,并且耐受良好. 虽然复发率仍然很高,但观察到病变严重程度显著降低,这需要进一步调查.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 扩散性鼻腔外性乳头瘤 (DSNEPs) 是罕见的,在外科切除后经常复发.
- 复发性呼吸道乳头炎 (RRP) 与DSNEP有相似之处,并使用贝瓦西祖马布治疗.
- 目前尚不清楚贝瓦西祖马布在DSNEP治疗中的疗效.
研究的目的:
- 为了评估初步经验,安全性,以及作为DSNEP的辅助疗法的sublesionalbevacizumab注射的结果.
- 评估贝瓦西祖马布对DSNEP严重程度和复发率的影响.
主要方法:
- 对七名DSNEP患者进行了回顾性,单中心的研究,这些患者接受了手术和次次注射贝瓦西祖马布的注射 (2011-2018).
- 进行了人类乳头瘤病毒 (HPV) DNA检测.
- 使用开发的得分来评估治疗效果来量化损伤严重程度.
主要成果:
- 所有7名患者都是男性,平均年龄为42岁. 在85.7%的患者中检测到HPV-11,在14.3%的患者中检测到HPV-6.
- 复发发生在85.72%的患者中,治疗后3年的中位数.
- 观察到严重程度得分的统计学显著降低 (p=0.017),没有报告重大并发症.
结论:
- 亚伤性贝瓦西祖马布注射是DSNEP的可行和耐受良好的辅助治疗方法.
- 尽管复发率很高,但贝瓦西祖马布在降低病变严重程度方面可能具有潜在的益处.
- 需要进行更大规模的前性研究,以确认贝瓦齐祖马布在DSNEP治疗中的安全性和有效性.
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