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身体活动和肝纤维化:按肥胖和糖尿病状况进行分层分析
Junghwan Cho1, Sunghwan Suh1, Ji Min Han1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea.
Journal of clinical medicine
|January 28, 2026
概括
定期进行中度至强度的休时间体育活动 (LTPA) 与肝纤维化发生的可能性较低有关. 无论肥胖或糖尿病状况如何,这种好处都会持续下去,突出了LTPA的特点.
科学领域:
- 肝病学和胃肠道学
- 公共卫生和流行病学
- 运动科学 运动科学
背景情况:
- 肝纤维化是一个严重的健康问题,往往会发展为严重的肝病.
- 生活方式因素,特别是体力活动在肝纤维化风险中的作用正在调查中.
- 肥胖和糖尿病是已知的肝病风险因素,可能与身体活动的影响相互作用.
研究的目的:
- 检查休时间体育活动 (LTPA) 与临床显著肝纤维化之间的关联.
- 为了确定肥胖和糖尿病状态是否改变了LTPA和肝纤维化之间的关系.
主要方法:
- 美国成年人的横截面分析来自2017-2020年国家健康和营养检查调查 (NHANES).
- 通过全球体力活动问卷 (GPAQ) 评估的LTPA;被分类为活跃 (≥600MET分钟/周) 或不活跃.
- 通过肝硬度测量 (LSM) 定义的临床显著肝纤维化≥8.0kPa;使用多变量回归.
主要成果:
- 身体活跃的参与者 (n=2721) 与不活跃的人 (11.4%) 相比,显著纤维化 (5.4%) 的患病率较低.
- 活跃的LTPA独立地与42%较低的显著肝纤维化几率相关 (OR0.58,95% CI 0.41-0.82).
- 对LTPA的保护性关联在各个子组中保持一致,包括非肥胖 (BMI <30 kg/m2) 和非糖尿病患者.
结论:
- 定期的中度至强度的LTPA独立地与临床显著肝纤维化的可能性降低有关.
- 无论肥胖或糖尿病状况如何,LTPA对肝纤维化的有益作用都很明显.
- 对于患有进展性肝病风险较高的人来说,LTPA可能是一个至关重要的,可访问的干预措施.
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