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治疗性结肠炎的目标:现在有多快?
Laura Parisio1, Giuseppe Cuccia1, Giuseppe Privitera2
1UOS Gastroenterologia, Ospedale Isola Tiberina Gemelli Isola, 00186 Rome, Italy.
治疗到目标的策略旨在通过监测炎症和升级治疗来完全控制性结肠炎 (UC) 的疾病. 目前的证据表明,许多UC患者仍然无法控制,这突显了需要改进管理方法的需要.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床治疗学 临床治疗学
背景情况:
- 性结肠炎 (UC) 是一种进展性炎症性肠病,需要超出症状控制的高级管理.
- 治疗目标已经转向实现缓解 (内镜,组织学),以获得更好的长期结果.
- 疾病清除,包括临床,内镜和组织学愈合,是UC的最终治疗目标.
研究的目的:
- 探索目前的证据和治疗肠炎 (UC) 管理中的治疗目标策略的未来方向.
- 评估在UC的常规临床实践中治疗到标方法的实施和有效性.
- 为了确定挑战和未满足的需求在实现完整的疾病控制UC患者.
主要方法:
- 对UC中治疗到目标策略的当前文献的综述.
- 根据STRIDE II标准对UC患者控制的最新现实数据的分析.
- 讨论支持和限制在UC中治疗到目标方法的应用的证据.
主要成果:
- 一种治疗到点的方法,如STRIDE II,被建议用于UC,但与克罗恩病相比,缺乏强有力的证据.
- 根据STRIDE II标准,近一半的UC患者目前的治疗方法无法充分控制.
- 控制不足的原因包括过度使用类固醇,持续性炎症,肠外表现和生活质量的降低.
结论:
- 治疗到目标的策略对于优化性结肠炎管理和实现严格的结果至关重要.
- 需要进一步的研究和临床验证来完善和有效地在UC中实施这些策略.
- 解决有效的UC治疗障碍对于改善患者的治疗结果和生活质量至关重要.
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