头部和部黑色素瘤的哨兵节点活检:来自中型区域中心的12年经验
Péter Lázár1, Kristóf Boa1, Noémi Mezőlaki2
1Department of Oral- and Maxillofacial Surgery, University of Szeged, 6720 Szeged, Hungary.
Journal of clinical medicine
|January 28, 2026
概括
哨兵淋巴结活检 (SLNB) 是一种安全有效的头 (H&N) 皮肤黑色素瘤分期程序. 这个关键工具为区域中心的患者选择提供了关键的预后信息.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 皮肤病学 皮肤病学
背景情况:
- 头部和部 (H&N) 皮肤黑色素瘤与其他部位相比,预后较差.
- 哨戒淋巴结活检 (SLNB) 是节点负性疾病的重要预后工具,在H&N黑色素瘤中未得到充分利用,特别是在专门中心之外.
研究的目的:
- 评估SLNB对H&N皮肤黑色素瘤的可行性和预后意义.
- 在一个中等规模的区域性机构中评估SLNB.
主要方法:
- 对38名初级H&N皮肤黑色素瘤患者进行SLNB (2010-2022) 的回顾性审查.
- 对临床病理特征,结节结局,复发模式,无复发生存率 (RFS) 和整体生存率 (OS) 的分析.
- 卡普兰-梅尔方法和单变Cox回归被用于生存分析.
主要成果:
- 在没有重大并发症的情况下实现了100%的哨兵淋巴结识别率.
- 在8名患者 (21.1%),确定了阳性哨兵淋巴结,错误缺失率为6.7%.
- 阴性SLN患者呈现较长RFS和OS的趋势;18.5%的中等风险黑色素瘤具有阳性SLN.
结论:
- SLNB是H&N黑色素瘤的安全和临床价值的分期程序,即使在中等体积的区域中心.
- 哨兵节点状态提供了关键的预后数据,有助于为现代辅助疗法选择患者.
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