处方实践,多药和抗凝剂治疗中的药物相互作用风险:来自二级护理医院的见解
Javedh Shareef1, Sathvik Belagodu Sridhar1, Shadi Ahmed Hamouda2
1Department of Clinical Pharmacy & Pharmacology, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
Journal of clinical medicine
|January 28, 2026
概括
多药性和潜在的药物相互作用 (pDDI) 在接受抗凝剂治疗的患者中很常见,特别是患有并发症的老年人. 管理这些风险需要医疗保健提供者之间的协作方法,以改善患者的治疗结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 老年病的医生 老年病的医生
背景情况:
- 抗凝剂对于心血管和血栓栓塞性疾病至关重要.
- 多种药物增加了潜在的药物相互作用 (pDDI) 的风险在服用抗凝剂的患者.
- 在抗凝固药治疗中,有效管理pDDI是一个重大挑战.
研究的目的:
- 评估抗凝血剂的处方趋势.
- 评估多药和pDDI在接受抗凝药治疗的患者的影响.
- 在二级护理环境中识别与多药和pDDI相关的因素.
主要方法:
- 从2023年1月到6月进行了一项横截面观测研究.
- 用Micromedex 2.0.0分析了处方数据,以发现抗凝剂处方模式和pDDI使用Micromedex 2.0.0.
- 使用后勤回归模型来评估多药,社会人口因素和pDDI之间的关系.
主要成果:
- 包括130名患者;女性 (58.46%) 和61-90岁的个人占主导地位.
- 心房动是主要的适应症,而阿皮克萨班是最常被处方的抗凝剂 (51.53%).
- 多药性与年龄,查尔森并发症指数 (CCI) 和并发症数量有显著的相关性. 药物的数量是pDDI的强有力的预测指标 (aOR:30.514,p=0.001).
结论:
- 多药和pDDI在接受抗凝药治疗的患者中很普遍.
- 年龄,CCI,并发症和药物的数量与多药和pDDI密切相关.
- 建议采用与临床决策支持系统的协作多维方法,以优化管理并提高患者的治疗结果.
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