疑似败血性关节炎中的三角中性粒细胞指数:一种诊断准确性研究
Hüseyin Emre Tepedelenlioğlu1, Hilmi Alkan1, Tural Talıblı1
1Department of Orthopedics and Traumatology, Ankara Etlik City Hospital, Ankara 06170, Türkiye.
Journal of clinical medicine
|January 28, 2026
概括
与传统的炎症标志物相比,三角中性粒细胞指数 (DNI) 在诊断败血性关节炎方面显示出更高的准确性. 这种快速的生物标志物有助于对关节感染的早期风险分层.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 生物标志物发现发现
背景情况:
- 败血性关节炎是一种骨科紧急情况,需要快速诊断以防止关节损伤.
- 目前的炎症生物标志物在快速区分败血症和非传染性关节炎方面存在局限性.
- 三角中性粒细胞指数 (DNI) 量化不成熟的粒细胞,并可能提供诊断价值.
研究的目的:
- 评估DNI对本地关节败血性关节炎的诊断性能.
- 为了比较DNI的准确性与传统的炎症生物标志物 (CRP,ESR,WBC,PCT) 和突液分析.
主要方法:
- 对85名成年人进行了回顾性分析,这些成年人因疑似感染性关节炎而接受了手术灌.
- 测量了血清CRP,ESR,WBC,DNI和PCT;记录了突白细胞计数.
- 通过突培养或临床判断确定感染状态;使用ROC曲线和AUC评估诊断准确性.
主要成果:
- DNI表现出最高的诊断歧视 (AUC=0.914与培养),表现优于CRP,ESR,WBC和PCT.
- 对文化而言,DNI获得了平衡的敏感性 (94.3%) 和特异性 (84.0%),具有高负预测值 (95.5%).
- 在其他生物标志物没有的情况下,在培养负的情况下,DNI仍然具有歧视性.
结论:
- 与传统的炎症标志物相比,DNI对本地关节败血性关节炎的诊断准确度更高.
- 作为一个易于获得的参数,DNI可以支持早期风险分层和规则的决定,怀疑性关节炎.
- 应将DNI作为临床评估和突液分析的辅助工具.
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