在传染性角膜炎中角膜移植的当前挑战和长期结果-系统性审查
Ancuța-Georgiana Onofrei1,2, Alina Gabriela Gheorghe3,4, Ana Maria Dascalu1,4,5
1Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Journal of clinical medicine
|January 28, 2026
概括
治疗性角膜整形可以在严重的微生物角膜炎中保存地球,但视觉结果通常是有限的. 感染类型和移植体大小等因素影响成功,需要进一步研究以改善功能结果.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 手术科学 手术科学
背景情况:
- 传染性角膜炎是全球失明的主要原因之一.
- 对于晚期病例,尽管使用了抗菌药物治疗,但治疗性角质塑造术通常是必要的.
研究的目的:
- 系统地审查微生物角膜炎治疗角膜整形术的结果.
- 确定影响解剖成功,移植存活和视觉康复的因素.
主要方法:
- 按照PRISMA指南 (2000-2025) 进行系统审查.
- 包括具有≥10个眼睛和≥6个月随访的研究.
- 提取有关感染控制,移植清晰度,视力敏度和并发症的数据.
主要成果:
- 对14项研究 (1527只眼睛) 的分析;89%接受TPK,选择性使用DALK.
- 感染控制 (69-100%),地球保护 (85-100%). 细菌性角质炎显示出比真菌/阿坎他梅巴更好的结果.
- 较大的移植体和深层干干涉增加了并发症;当内皮被遗留时,DALK改善了移植体的存活率.
结论:
- 治疗性角膜整形有效地保护了地球在先进的微生物角膜炎.
- 功能性结果仍然有限,受疾病严重程度和手术时间的影响.
- 需要进行进一步的研究,以优化手术指示和术后管理.
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