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系统性免疫炎症指数在粘膜恶性黑色素瘤的预后值

Burak Paçacı¹, Erkam Kocaaslan¹, Ahmet Demirel¹

¹Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Marmara University, Istanbul 34854, Turkey.

Journal of clinical medicine

|January 28, 2026

概括

系统性免疫炎症指数 (SII) 可以预测粘膜癌恶性黑色素瘤 (MMM) 的结果. 治疗前高SII水平与MMM患者的整体存活率 (OS) 较差有关,提供了一个新的预后工具.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物研究生物标志物研究

背景情况:

粘膜性恶性黑色素瘤 (MMM) 是一种罕见的,具有不良预后的侵袭性癌症.
系统性免疫炎症指数 (SII) 是固体瘤的潜在预后标志物,但其在MMM中的作用尚不清楚.

研究的目的:

在患有粘膜恶性黑色素瘤 (MMM) 的患者中调查治疗前系统性免疫炎症指数 (SII) 和整体存活率 (OS) 之间的关联.

主要方法:

来自六个土耳其瘤中心的106名成年MMM患者 (2005-2025) 的回顾性分析.
在治疗前计算基线SII (血小板 × 中性粒细胞/淋巴细胞计数).
ROC分析确定了OS预测的最佳SII截止值为776.

主要成果:

与低SII (<776) 相比,高预治疗SII (≥776) 与显著更短的OS (16.2 vs 35.2个月) 相关.
多变量分析证实高SII,胃肠道主要部位和转移性疾病作为更糟糕的OS的独立预测因素.
患有高SII的患者表现出更具侵略性的疾病特征和较差的生存结果.

结论:

系统性免疫炎症指数 (SII) 是一种新的,独立的,用于膜恶性黑色素瘤 (MMM) 的预后生物标志物.
治疗前增加的SII与积极的临床病理特征以及降低整体存活率相关.
在常规MMM患者护理中,SII提供了一种具有成本效益的工具,以改善风险分层.

关键词:

系统性免疫炎症指数生物标志物生物标志物粘膜上的黑色素瘤总体存活率总体存活率预后预后预后

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