患有Coxiella burnetii急性感染的患者的自主功能障碍
Branislav Milovanović1,2, Nikola Marković1, Elizabeta Ristanović3
1Institute for Cardiovascular Diseases "Dedinje", 11040 Belgrade, Serbia.
菌燃烧菌感染可以导致持续的自主神经系统 (ANS) 功能障碍,特别是影响了副交感调节. 这可能会导致肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和患者昏.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 心脏病学 心脏病学
背景情况:
- Coxiella burnetii是一种引起Q热和后传染性综合征的动物性病原体.
- 自主神经系统 (ANS) 功能障碍是这些综合征中可疑的机制.
- 研究了患有C. burnetii感染的ME/CFS和dysautonomia患者.
研究的目的:
- 在患有C. burnetii感染的患者中评估自主功能.
- 为了调查C. burnetii与dysautonomia和ME/CFS等症状之间的联系.
- 为了评估病毒阳性个体的ANS损伤.
主要方法:
- 156名参与者 (100名C. burnetii病毒阳性,56名对照) 进行了评估.
- 进行了心血管反射测试 (CART),节拍分析和24小时霍尔特心电图与HRV.
- 头向上倾斜测试 (HUTT) 在C. burnetii组中进行.
主要成果:
- 在C. burnetii组中,自主功能障碍的患病率更高,主要是副交感性.
- 观察到异常的CART得分,LF功率降低和巴罗反射效率.
- 积极的HUTT发现与极端的血压变化和受损的短期HRV指数表明ANS损伤.
结论:
- C. burnetii感染可能会引发持续的自主功能障碍.
- 这种功能障碍可能会导致ME/CFS和昏迷的发展.
- 为了获得病理生理学和临床见解,需要进一步的研究.
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