区分肺结核与社区获得的肺炎的临床指标在老年人中:一个前性的多中心研究
Mari Yamasue1,2, Kosaku Komiya1, Tetsuji Nakano2
1Respiratory Medicine and Infectious Diseases, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi 879-5593, Oita, Japan.
Pathogens (Basel, Switzerland)
|January 28, 2026
概括
老年人肺结核 (PTB) 的临床指标与年轻人不同. 关键症状包括体重减轻,症状延长,缺乏疲劳或呼吸障碍,有助于区分PTB与社区获得性肺炎 (CAP).
科学领域:
- 老年病的医生 老年病的医生
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 肺结核的临床指标主要基于年轻人群.
- 老年人 (≥65岁) PTB 的诊断线索尚未得到充分验证.
- 在老年人中区分PTB与社区获得性肺炎 (CAP) 是一个临床挑战.
研究的目的:
- 在65岁及以上的患者中确定区分PTB与CAP的临床特征.
- 为改善老年人群结核病诊断提供证据.
主要方法:
- 多中心前性观察性研究.
- 招募了233名被诊断患有PTB或非TBCAP的患者 (≥65岁).
- 使用多变量逻辑回归,比较PTB和CAP组之间的人口统计,症状和实验室发现.
主要成果:
- 在57名 (24%) 患者中诊断出肺结核 (PTB).
- PTB组年龄较大,表现状况较差.
- 预测PTB的独立预测因素包括体重减轻 (aOR 8.17),症状≥2周 (aOR 5.79),没有疲劳 (aOR 0.19),没有呼吸障碍 (aOR 0.19).
- 夜间出汗和血并不是显著的歧视因素.
结论:
- 体重减轻,症状延长,缺乏整体疲劳或呼吸障碍是老年人PTB的有价值的临床指标.
- 这些发现可以为老龄化人口的结核病控制策略提供信息.
- 进一步的研究可能会完善老年人PTB的诊断方法.
相关概念视频
Pulmonary Tuberculosis I
923
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
923
Pulmonary Tuberculosis II
1.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.5K
Pulmonary Tuberculosis V
586
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
586
Pulmonary Tuberculosis III
1.0K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.0K
Pulmonary Tuberculosis IV
514
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
514
Indicators
60.5K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
60.5K


