急性呼吸道感染中的肠道病毒-D68-被忽视的病原体:克罗地亚的见解
Zeljka Hruskar1, Lucija Skara Abramovic1, Ivana Ferencak1
1Microbiology Department, Croatian Institute of Public Health, 10000 Zagreb, Croatia.
Pathogens (Basel, Switzerland)
|January 28, 2026
概括
肠道病毒D68 (EV-D68) 在克罗地亚得到证实,流传的血统与欧洲的血统相匹配. 加强监测对于了解EV-D68的流行病学至关重要,因为可能报告不足.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 2014年,D68型肠道病毒 (EV-D68) 爆发在全球范围内有所增加,但由于监测有限,克罗地亚的报道仍然不足.
- 在2022年欧洲爆发后,克罗地亚呼吸道样本中开始对EV-D68进行系统性表征.
研究的目的:
- 确认在克罗地亚存在EV-D68.
- 通过遗传学分析识别循环的EV-D68血统.
- 评估该地区EV-D68的流行病学趋势.
主要方法:
- 来自急性呼吸道感染患者的呼吸道样本使用实时RT-qPCR测试了EV和EV-D68.
- 对EV-D68阳性样本进行了测序,以获得VP1基因序列用于遗传学分析.
主要成果:
- 在2022年3月至2024年12月期间,在2048个样本中检测到EV.
- 2022年,EV-D68在13.1%的EV阳性样本中被发现,在2023年下降,并在2024年上升至19.6%.
- 遗传学分析揭示了A2和B3两种类型,B3在2022年占主导地位,A2在2024年被新引入.
结论:
- 克罗地亚的EV-D68存在和流传的血统与欧洲的发现一致.
- 由于缺乏常规检测,可能导致低估了EV-D68的患病率.
- 持续的监测和基因组表征对于澄清克罗地亚的EV-D68流行病学至关重要.
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