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相关概念视频

Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

40.0K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
40.0K
Functions of Connective Tissues01:17

Functions of Connective Tissues

16.4K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
16.4K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

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VSEPR Theory for Determination of Electron Pair Geometries
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Tissues01:18

Tissues

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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
85.1K
Tissue-Drug Binding: Localization of Drugs and its Significance01:24

Tissue-Drug Binding: Localization of Drugs and its Significance

438
Body tissues, comprising approximately 40% of the body weight, are crucial in drug distribution and localization. These tissues can serve as drug storage sites, competing with plasma binding sites for drug molecules.
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...
438
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

4.0K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
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相关实验视频

Updated: Jan 29, 2026

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
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Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

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工程人类3D心脏组织用于预测功能性药物查.

Ester Sapir Baruch1,2,3,4, Daniel Rosner1,3,4, Elisabeth Riska1,3,4,5

  • 1The Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Pharmaceutics
|January 28, 2026
PubMed
概括

这项研究开发了一种新的3D人类心脏组织平台,用于药物诱导心脏毒性查. 先进的体外模型准确地预测了人类的心脏反应,改善了临床前药物安全测试,减少了动物使用.

关键词:
3D体外模型 3D体外模型心脏有毒性心脏有毒性药物查对药物进行查.由hiPSC衍生的心脏组织.

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Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues

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相关实验视频

Last Updated: Jan 29, 2026

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科学领域:

  • 生物医学工程 生物医学工程
  • 心血管研究研究心血管研究
  • 药物发现 药物发现 药物发现

背景情况:

  • 心脏毒性是戒药的主要原因之一.
  • 目前的临床前模型 (二维培养,动物研究) 在预测人类心脏反应方面存在局限性.
  • 需要与人类相关的体外平台来评估心脏毒性.

研究的目的:

  • 开发一个高通量,人体相关的体外平台,用于预测性心脏毒性查.
  • 利用来自人类诱导多能干细胞 (hiPSCs) 的3D心脏组织.
  • 为了能够对药物对心脏组织的影响进行功能性评估.

主要方法:

  • 在热敏水凝中,从hiPSC中设计出3D心脏组织.
  • 使用免疫染色和成像验证的组织成熟.
  • 通过视频分析量化收缩性能 (心跳率,收缩幅度).
  • 测试了各种心脏活性化合物的剂量依赖作用.

主要成果:

  • 工程心脏组织表现出功能成熟和稳定的收缩行为.
  • 药物测试揭示了特定于化合物的,剂量依赖的功能反应.
  • 该平台准确地复制了测试化合物的预期生理反应.

结论:

  • 开发的可扩展平台提供了对心脏组织的敏感,多参数功能评估.
  • 这种具有成本效益的工具可以提高临床前药物安全性测试和翻译准确性.
  • 该平台减少了对心脏毒性评估的动物模型的依赖.