基于实验和建模的方法,用于机械理解面板涂层过程-详细审查
Behrad Aminahmadi1,2, Elise Vaes3, Filip Willemse3
1Pharmaceutical Engineering Research Group (PharmaEng), Department of Pharmaceutical Analysis, Ghent University, Campus Heymans, Ottergemsesteenweg 460, 9000 Gent, Oost-Vlaanderen, Belgium.
这篇评论探讨了平板电脑薄膜涂层,重点是混合,喷和蒸发. 整合实验和基于模型的方法是涂料工艺的强大,以质量为导向的控制的关键.
科学领域:
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
背景情况:
- 片薄膜涂层涉及复杂的现象:片混合,喷涂涂层和液体蒸发.
- 这些现象极大地影响了最终产品的关键质量属性 (CQAs).
研究的目的:
- 审查涂层设计,工艺参数和质量控制如何影响涂层变化.
- 评估过程优化的实验和基于模型的方法.
主要方法:
- 实验设计 (DOE) 和过程分析技术 (PAT) 以获得实证见解.
- 热力学,喷雾动力学和粒子动力学建模用于机械学理解.
主要成果:
- 涂层设计,工艺参数和质量控制策略显著影响涂层的统一性.
- 实验和建模方法为热量/质量转移和滴滴动态提供了互补的见解.
结论:
- 目前还没有针对整个涂层过程的全面预测模型.
- 未来的进步需要整合实验和基于模型的预测控制方法.
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