多发性硬化症的细胞疗法:临床研究的临床进展,局限性和未来前景-系统性审查
Ola Mohamed Fathy Kamal1,2, Doddy Denise Ojeda-Hernández1, Belén Selma-Calvo1
1Laboratorio de Neurobiología y Terapias Avanzadas, Instituto de Neurociencias, Instituto de Investigación Sanitaria San Carlos (IdISSC), Hospital Clínico San Carlos, 28040 Madrid, Spain.
Pharmaceutics
|January 28, 2026
概括
基于细胞的疗法对多发性硬化症 (MS) 治疗有希望. 自主造血干细胞移植 (AHSCT) 为活跃的MS提供缓解,而介质干细胞 (MSC) 和神经干细胞 (NSC) 正在研究神经再生.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统自身免疫性疾病,导致炎症,脱髓化和神经退行.
- 目前的疾病修饰疗法 (DMT) 可以控制复发,但很少阻止进展或修复损伤.
- 基于细胞的疗法在MS中具有免疫调节和神经再生的潜力.
研究的目的:
- 审查当前的临床证据,以细胞为基础的人类MS治疗.
- 评估自身造血干细胞移植 (AHSCT),介质干细胞 (MSCs) 和神经干细胞/原生细胞 (NSCs).
主要方法:
- 在PubMed,Scopus和ClinicalTrials.gov.gov的系统文献搜索.
- 专注于符合特定纳入标准的人类临床试验.
- 对基于细胞的MS疗法现有临床数据的审查.
主要成果:
- 尽管存在程序性风险,AHSCT在高度活跃的复发性复发性MS (RRMS) 中显示出一致的长期免疫复原和缓解.
- 介质干细胞 (MSC) 疗法显示出安全性和生物活性,特别是在渐进性多发性硬化症中,内 (IT) 输送,但临床结果各不相同.
- 神经干细胞 (NSC) 治疗处于早期研究阶段,这表明中枢神经系统修复的潜力.
结论:
- AHSCT对活跃的MS有效,而MSC和NSC对渐进的MS和中枢神经系统修复有前途.
- 限制包括协议变化,小样本大小和短的随访时间.
- 大规模的随机对照试验对于确认疗效,优化药物输送和标准化方案至关重要.
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