植物纳米纤维伤口包装装载有Psidium guajava叶子提取物:制备,表征和体内评估
Menna M Abdellatif1, Hesham A Eliwa2, Mohamed Aly Abd El Aziz El Degwy3
1Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza 12566, Egypt.
Pharmaceutics
|January 28, 2026
概括
装有果叶提取物的植物纳米纤维促进了有效的伤口愈合. 优化的冷干燥和电技术,与商业奶油相比,产生了优越的再生医学敷料.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 开发有效的伤口愈合策略至关重要.
- 植物提取物为组织修复提供治疗潜力.
- 瓜 (瓜) 叶提取物Psidium guajava (瓜) 叶提取物具有生物活性化合物.
研究的目的:
- 开发和评估带有Psidium瓜叶提取物增强伤口愈合的植物纳米纤维.
- 优化冷干燥参数以最大限度地提高生物活性化合物含量.
- 在体内评估纳米纤维带的疗效.
主要方法:
- 一个2^3的因数设计优化了冷干燥参数 (冷时间,真空,冷化时间).
- Psidium guajava 叶子提取物通过电旋转装入聚氨纳米纤维.
- 纳米纤维的特点是多/黄含量,表面形态和粗度.
- 在体内进行了伤口愈合研究,组织病理学和分子分析 (细胞因子,MMP,生长因子).
主要成果:
- 最佳的冷干燥条件产生了高的总聚 (96%) 和黄 (91.83%) 含量.
- 电纳米纤维呈现出光滑,均的表面,粗度降低.
- 在体内研究表明,与商业Panthenol奶油相比,植物纳米纤维的伤口愈合优越.
- 组织病理学分析和分子标记器支持增强组织修复.
结论:
- 提取和冷化参数显著影响Psidium guajava叶提取物的生物活性.
- 开发的植物纳米纤维敷料显示了伤口修复和再生医学的巨大潜力.
- 这种方法为传统的伤口护理治疗提供了一个有希望的替代方案.
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