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基于激光的QR码标记在双薄膜涂层平板电脑上:平衡标记效率和平板电脑完整性-迈向更安全的药物的一步
Hadi Shammout1, Béla Hopp2, Tamás Smausz2
1Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Pharmaceutics
|January 28, 2026
概括
超快速激光标记QR码直接在布洛芬片上可以提高药物安全性和打击假冒. 仔细考虑激光参数和涂层至关重要,以保持平板电脑的完整性和药物释放概况.
科学领域:
- 制药技术 制药技术 制药技术
- 激光处理是激光处理的过程.
- 药物输送系统是药物输送系统.
背景情况:
- 激光标记对于固体剂型 (SDF) 在制药行业至关重要.
- 打击伪造药品需要创新的反假冒措施,而不仅仅是包装序列化.
- 直接用QR码标记平板电脑提供了一个潜在的解决方案,以提高可追溯性.
研究的目的:
- 通过使用超快激光来评估双层膜涂布布洛芬片上的QR码标记.
- 评估激光标记对药片功能完整性和药物释放的影响.
- 确定基于激光的QR码标记在工业相关速度的可行性.
主要方法:
- 药片被涂上了耐胃和立即释放的层 (含有TiO2和无TiO2).
- 通过使用具有各种参数的超高速Ti:Sa激光来删除QR码.
- 进行了物理,化学和显微镜分析,包括SEM,拉曼和体外溶解.
主要成果:
- 在含有TiO2和不含TiO2的涂层之间没有发现显著差异.
- QR 代码的可读性取决于激光设置和涂层类型.
- 激光实现了高速,高精度的标记,潜在的经济可行性.
- 可以通过适当的涂层厚度来管理除深度,以保持所需的药物释放.
结论:
- 药剂表格上的超快激光QR码标记对医疗保健和药物可追溯性具有显著的好处.
- 对剂型行为的潜在不良影响需要仔细的配方和激光参数选择.
- 延迟释放 (DR) 系统需要特别注意,以确保功能完整性.
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