从经典到纳米辅料和生物聚合物:肺部药物输送配方
Maria Nikou1, Maria Chountoulesi1, Stergios Pispas2
1Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.
Pharmaceutics
|January 28, 2026
概括
本综述详细介绍了干粉吸入器 (DPI) 助剂,解决了缺乏全面清单的问题. 了解DPI配方特征有助于未来的研究和吸入技术中的辅助剂选择.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 吸入科学 吸入科学
背景情况:
- 干粉吸入器 (DPI) 对于肺部药物输送至关重要.
- 有限数量的已批准的辅助剂存在于吸入配方中.
- 辅助剂的选择是DPI配方开发中的关键步骤.
研究的目的:
- 对DPI配方中使用的辅助剂进行系统审查.
- 提供可用的DPI辅助剂的全面概述.
- 作为未来DPI配方研究的研究工具.
主要方法:
- 系统的文献审查和分析.
- 检查DPI配方的物理化学特性.
- 对DPI效率和药物释放概况的评估.
主要成果:
- 在DPI中使用的辅助剂的识别和编制.
- 详细分析DPI配方特性.
- 评估辅助剂对表现的影响.
结论:
- 目前缺乏对DPI助剂的全面了解.
- 这次审查为DPI配方组件提供了有价值的见解.
- 这些发现可以指导辅助剂的选择,以改善DPI开发.
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