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固体微针来自Poly ((3-基丁酸盐-co-3-基酸盐-co-3-基酸盐):一种无溶剂,可生物降解的药物输送平台

Diana Araújo^1,2, Francisco Santos^1,2,3, Rui Igreja³

¹UCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal.

|January 28, 2026

概括

这项研究表明,可生物降解的聚3-xybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate (PHBHVHHx) 微针可以以可持续的方式制造. 这些微针具有良好的机械强度,插入能力和药物输送潜力.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
可持续制造可持续制造可持续制造

背景情况:

传统的微针 (MNs) 通常使用非生物降解材料,这给环境带来了挑战.
开发可持续的替代品用于透皮输送器件对于减少浪费和改进加工至关重要.
聚3-xybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PHBHVHHx) 作为一种用于MN制造的新型生物聚合物正在探索中.

研究的目的:

评估PHBHVHHx在无溶剂制造固体微针阵列中的可行性.
评估PHBHVHHx微针的机械性能,插入能力和药物输送性能.
建立PHBHVHHx微针作为传统的透皮系统的可持续替代品.

主要方法:

在200°C下对PHBHVHHx进行无溶剂微型成型,以创建微针阵列.
使用扫描电子显微镜进行形态分析.
通过使用Parafilm皮肤仿真剂进行轴向压缩和插入评估进行机械测试.
在体外药物释放研究中,使用二甲和UV-Vis光谱学.

主要成果:

PHBHVHHx微针呈现出利的圆形状 (681±45微米长) 和微纹理的表面.
微针表现出强大的机械强度 (0.25 ± 0.03 N/针) 并达到约396微米的插入深度.
药物涂层的微针显示药物释放速度很快,约73%的二甲在10分钟内释放.

结论:

PHBHVHHx是一种合适的生物降解热塑料,用于制造使用无溶剂方法的固体微针阵列.
制造的PHBHVHHx微针具有足够的机械完整性和插入能力.
这些发现支持PHBHVHHx微针作为通过皮肤递送药物的环保替代品的潜力.

关键词:

有涂层的MNs.聚3-xybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) 是一种聚酸的化合物,它在酸中含有多种化合物.固体微针 (MN) 阵列的组件没有溶剂的微型成型.通过皮肤传递药物.

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