朱尼珀斯共产L.针提取物在急性炎症实验模型中调节氧化和炎症途径
Dinu Bolunduț1,2, Alina Elena Pârvu1, Andra Diana Cecan1
1Department of Morphofunctional Sciences, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Molecules (Basel, Switzerland)
|January 28, 2026
概括
(J. communis) 针提取物显示出显著的抗氧化和抗炎作用. 这项研究为其在治疗炎症和氧化应激方面的传统医疗用途提供了科学验证.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- (J. communis) 传统上在欧洲医学中用于治疗炎症.
- 共产的抗氧化和抗炎机制提取物需要进一步的科学阐明.
研究的目的:
- 为了研究乙醇的J. communis针提取物的抗氧化和抗炎潜力.
- 为了描述提取物的植物化学概况.
- 在急性炎症的体内模型中评估提取物的疗效.
主要方法:
- 使用二极管阵列检测和电子喷雾电离质谱仪 (HPLC-DAD-ESI-MS) 的高性能液态染色学进行植物化学分析.
- 在体外抗氧化剂测定包括DPPH,过氧化,降铁和氧化清理.
- 在体内评估大鼠中油诱导的急性炎症,测量氧化应激标志物和炎症性细胞因子.
主要成果:
- .共产的提取物富含多,特别是氨酸衍生物和taxifolin.
- 在体外试验证实了显著的激素清除和减少活动.
- 在体内给药降低了氧化应激标志物 (马隆迪阿尔海德,先进的氧化蛋白产物,8-基-2'-脱氧氨酸) 和炎症调解剂 (介质素-1β,介质素-18),抑制了NF-κB活性,并恢复了抗氧化能力.
结论:
- 乙醇的J.communis针提取物具有显著的抗氧化和抗炎性质.
- 这些发现支持传统使用J.communis治疗炎症疾病.
- 该研究证实了J.communis提取物的治疗潜力,基于其植物化学成分和证明的生物活性.
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