来自Tremella mesenterica的多糖化合物的结构光和保湿潜力
Geu-Rim Song1, Hye-Ryung Park2, Hye-Won Lee1
1Development Team, Skin Research Team, Department of Skin & Natural Products Lab, Kolmar Korea Co., Ltd., Seoul 06800, Republic of Korea.
Molecules (Basel, Switzerland)
|January 28, 2026
概括
特雷梅拉 (Tremella mesenterica) 聚糖 (TMP) 通过增强皮肤屏障蛋白和水分因子,显示出有前途的保湿作用. 这种黄色的大脑真菌衍生物可能在化品和药品中提供好处.
科学领域:
- 生物化学 生化学
- 皮肤病学 皮肤病学
- 菌类学 菌类学是指菌类学.
背景情况:
- 一种药用真菌Tremella mesenterica具有传统的用途.
- 多糖是众所周知的各种生物活动.
- 了解多糖的结构-功能关系对于应用至关重要.
研究的目的:
- 为了阐明Tremella mesenterica多糖体 (TMP) 的结构特征.
- 为了评估TMP的体外保湿潜力.
- 为了比较TMP与Tremella fuciformis多糖 (TFP) 和酸 (HA) 的疗效.
主要方法:
- 用酶辅助提取用于TMP隔离.
- 甲基化和气色谱-质谱 (GC-MS) 用于结构分析.
- 定量逆转录聚合酶连锁反应 (qRT-PCR) 和免疫细胞化学 (ICC) 来评估基因和蛋白质表达.
主要成果:
- TMP的分子量约为143kDa,具有特定的单糖化合物组成.
- 在TMP上调节了水素-3 (AQP3),氨酸合成酶-2 (HAS2) 和费拉格林 (FLG) 等关键保湿因子.
- TMP显著提高了氨酸合成酶-3 (HAS3) 蛋白质水平.
结论:
- 通过调节皮肤水分和屏障功能,TMP在体外表现出显著的保湿潜力.
- 的结构性质支持其作为保湿剂的有效性.
- 酸是化品,食品,生物聚合物和制药领域应用的有希望的候选物.
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