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克尔西加载的Zin/Carboxymethyl Chitosan纳米颗粒:用于增强稳定性和抗氧化活性的制备,表征和评估

Haiqi Yu¹, Wanjun Chen¹, Yuhong Su¹

¹Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.

Molecules (Basel, Switzerland)

|January 28, 2026

概括

泽因/碳甲基酸盐纳米颗粒 (ZCQ NPs) 有效封装奎尔素,增强其稳定性和抗氧化特性. 这些纳米颗粒提供了一个有前途的解决方案,用于输送Quercetin,克服其可溶性和环境敏感性的局限性.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

奎尔是一种天然的黄类化合物,表现出强大的抗氧化,抗炎和抗动脉样硬化活性.
奎尔丁的治疗潜力受到其不良的水溶性和环境不稳定性的严重阻碍.
开发有效的输送系统对于最大限度地提高奎尔素的生物可用性和疗效至关重要.

研究的目的:

开发和表征素载/甲基基素纳米颗粒 (ZCQ NPs).
评估制造ZCQNP的稳定性和抗氧化能力.
评估 ZCQ NPs 作为奎尔塞丁先进药物递送系统的潜力.

主要方法:

用抗溶剂沉技术合成了带有素的/甲基基托桑纳米颗粒 (ZCQ NPs).
分析了ZCQNP的粒子大小,多分散度指数 (PDI) 和zeta潜力.
在各种条件下进行稳定性评估,包括光,热和离子强度,以及长期储存观察.
抗氧化能力通过自由基和活性氧物种 (ROS) 清除试验进行评估.

主要成果:

制造的ZCQ NP显示了小颗粒大小和低PDI,表明良好的单分散性.
ZCQ NPs的负泽塔电位为-41.50 ± 1.76 mV,这表明它们具有体稳定性.
这些纳米粒子对光,热和不同的离子强度表现出了显著的稳定性,并随着时间的推移保持了单分散性.
在清理试验中,ZCQ NPs与自由奎尔丁相比显示出显著增强的抗氧化能力.

结论:

含奎尔素的/甲基基托桑纳米颗粒 (ZCQ NPs) 是一种稳定有效的配方.
ZCQ NP系统成功地克服了自由氨酸的可溶性和稳定性限制.
这些纳米颗粒显示出相当大的希望,作为奎尔素的先进药物输送平台,增强其治疗应用.

关键词:

抗氧化剂活性抗氧化剂活性碳氧甲基基托桑是一种碳氧甲基基托桑.文素 (Quercetin) 是一种文素.稳定的稳定性稳定的稳定性这是一个很大的 zein zein zein.

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