雅奎蒙提亚丹塔 (Jacquemontia pentantha) 精油的化学成分,抗菌,抗氧化和抗癌活性
Noorah A Alkubaisi1, Mashail Fahad Alsayed1, Hissah Abdulrahman Alodaini1
1Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Molecules (Basel, Switzerland)
|January 28, 2026
概括
来自Jacquemontia pentantha的精油具有显著的抗氧化,抗菌和细胞毒性质. 这项研究支持其民族植物学用途,并表明开发新药剂的潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学 是一个学科.
- 民族植物学 民族植物学
背景情况:
- 杰克文蒙提亚桑 (Convolvulaceae) 具有丰富的植物学用途.
- 它的精油 (EO) 成分和生物特性在很大程度上尚未研究.
- 本研究旨在描述J. pentantha EO (JPEO),并评估其生物活动.
研究的目的:
- 为了描述J. pentantha EO (JPEO) 的化学特征.
- 评估JPEO的体外抗氧化,抗微生物和细胞毒性.
- 为民族植物学用途提供科学验证,并探索新的治疗潜力.
主要方法:
- 通过水蒸从空气部分分离了EO.
- 使用气体染色学质谱法 (GC-MS) 分析化学成分.
- 生物活动使用体外测试来评估:DPPH,ABTS,磁盘扩散,微乳液稀释和MTT测试.
主要成果:
- 在JPEO中,它表现出一种独特的化学特征,富含着甲烯类型的甲烯 (例如β-甲烯, (+) -α-甲烯) 和基单烯酸.
- 显著的抗氧化活性 (IC50 = 172.41μg/mL),高的含量 (97.34毫克GAE/g).
- 强大的抗菌活性 (MIC = 4.68 微克/毫升) 对抗 Pseudomonas aeruginosa,抗真菌活性对抗 Candida albicans (MFC = 3.90 微克/毫升),以及对 MCF-7 和 HepG2 细胞的剂量依赖性细胞毒性作用 (IC50 = 161.62 和 151.87 微克/毫升).
结论:
- J. pentantha EO是一种有前途的化合物来源,具有显著的抗菌和细胞毒性.
- 这些发现为J. pentantha.的传统使用提供了科学支持.
- JPEO具有开发用于感染和癌症治疗的新药剂的潜力.
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