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Updated: Jan 29, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
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在HDAC8主动站点中的金属偏好层次:DFT研究

Nikolay Toshev1, Diana Cheshmedzhieva2, Yordanka Uzunova1,3

  • 1Department of Bioorganic Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.

Molecules (Basel, Switzerland)
|January 28, 2026
PubMed
概括

(Zn2+) 是素脱乙酶8 (HDAC8) 的首选金属辅因子. 计算研究揭示了其优越的结合亲和力比其他离子,如Fe2+,Co2+,Ni2+和Mg2+.

关键词:
在DFT研究中,研究人员对DFT进行了研究.在HDAC8活性部位.这就是HDACi.金属竞争金属竞争金属离子选择性的金属离子选择性.

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