通过蒂奥尔-迈克尔点击反应重复性永久化:使用来自酸和氨酸的胺
Zezhi Liu1, Ling Ma1,2, Timson Chen2
1School of Chemical and Material Engineering (School of Cosmetics), Jiangnan University, Wuxi 214122, China.
这项研究引入了一种新型分子,用于在没有氧化损伤的情况下进行可重复的头发永久性. 这种新方法的结果与传统的永久性护发相提并论,同时在多个周期内保持头发的完整性.
科学领域:
- 化品科学 化品科学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 传统的头发永久化使用氧化剂,造成严重的头发损伤.
- 现有的醇-迈克尔点击永久化方法可以避免氧化损伤,但缺乏可重复性.
研究的目的:
- 为了开发一种新的醇-迈克尔点击永久分子,用于可重复的应用,而无需氧化损伤.
- 评估新永久化策略的有效性,安全性和保护头发的特性.
主要方法:
- 通过拉曼光谱和1H NMR.合成和表征N,N'-bis(maleoyl) -l-cystine (MA2-CySS) 使用拉曼光谱和1H NMR.
- 通过MTT测定进行细胞毒性评估.
- 在不同的pH值和温度条件下进行反应性分析.
- 评估永久性效率,颜色变化,皮层损伤 (SEM),机械性能和质蛋白结构保存 (拉曼光谱学).
主要成果:
- MA2-CySS没有显示出高达1000μg/mL的细胞毒性.
- 醇-迈克尔点击反应在30分钟内完成,在性pH和高温下具有最佳反应性.
- MA2-CySS永久化在三个周期内实现了高效率,与氧化永久化相当.
- 该方法显著减少了头发颜色的变化和皮质损伤,同时保持了卓越的机械性能.
- 拉曼光谱检测证实,与氧化永久性相比,头发角质蛋白的二次结构更好地保存,含有更高的α螺旋体含量,二硫化物键保留和有利的形状变化.
结论:
- 没有氧化损伤的重复性头发永久性可以通过醇-迈克尔点击化学实现,使用新的MA2-CySS分子.
- 这种创新方法为传统的永久性方法提供了更安全,更有效的替代方案,可以保持头发的质量.
- 这些发现代表了长发技术的重大进步,提高了性能和头发健康.
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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Acid-catalyzed hydrolysis:
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Acids, Bases and Neutralization Reactions
Acids, Bases and Neutralization Reactions
